ISLET BIOLOGY LAB
Publications
Learn about the results of our researched, published in international peer-reviewed journais
Marroqui L, Perez-Serna AA, Babiloni-Chust I, Dos Santos RS.
Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes.
Int Rev Cell Mol Biol. 2021;359:1-80.
doi: 10.1016/bs.ircmb.2021.02.011.
Dos Santos RS, Guzman Llorens D, Perez-Serna AA, Nadal A, Marroqui L
Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human beta cells against proinflammatory insults
bioRxiv. 2023
doi: https://doi.org/10.1101/2022.12.27.522037
Perez-Serna AA, Dos Santos RS, Ripoll C, Nadal A, Eizirik DL, Marroqui L
BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis
Int J Mol Sci. 2023 Mar; 24(6):5657.
doi: 10.3390/ijms24065657
:Dos Santos RS, Babiloni-Chust I, Marroqui L, Nadal A.
Screening of Metabolism-Disrupting Chemicals on Pancreatic α-Cells Using In Vitro Methods.
Int J Mol Sci. 2023 Jan; 24(1):231.
doi: 10.3390/ijms24010231
Dos Santos RS, Medina-Gali RM, Babiloni-Chust I, Marroqui L, Nadal A.
In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model.
Int J Mol Sci. 2022 May;23(9):5040
doi: 10.3390/ijms23095040
Babiloni-Chust I, Dos Santos RS, Medina-Gali RM, Perez-Serna AA, Encinar JA, Martinez-Pinna J, Gustafsson JA, Marroqui L, Nadal A.
G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells.
Environ Int. 2022 Jun;164:107250.
doi: 10.1016/j.envint.2022.107250
Marroqui L, Perez-Serna AA, Babiloni-Chust I, Dos Santos RS.
Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes.
Int Rev Cell Mol Biol. 2021;359:1-80.
doi: 10.1016/bs.ircmb.2021.02.011.
Marroqui L, Martinez-Pinna J, Castellano-Muñoz M, Dos Santos RS, Medina-Gali RM, Soriano S, Quesada I, Gustafsson JA, Encinar JA, Nadal A.
Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway.
Chemosphere. 2021 Feb;265:129051
doi: 10.1016/j.chemosphere.2020.12905.
Quesada-Candela C, Tudurí E, Marroquí L, Alonso-Magdalena P, Quesada I, Nadal Á.
Morphological and functional adaptations of pancreatic alpha-cells during late pregnancy in the mouse.
Metabolism. 2020 Jan;102:153963.
doi: 10.1016/j.metabol.2019.153963.ç
Martinez-Pinna J*, Marroqui L*, Hmadcha A, Lopez-Beas J, Soriano S, Villar-Pazos S, Alonso-Magdalena P, Dos Santos RS, Quesada I, Martin F, Soria B, Gustafsson JÅ, Nadal A.
Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.
(*) equal contribution
Diabetologia. 2019; 62(9):1667-1680.
doi: 10.1007/s00125-019-4925-y.
Marroqui L, Tudurí E, Alonso-Magdalena P, Quesada I, Nadal Á, Dos Santos RS.
Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes.
J Endocrinol. 2018; 239(2):R27-R45.
doi: 10.1530/JOE-18-0362.
Marroqui L, Dos Santos RS, Op de Beeck A, Coomans de Brachène A, Marselli L, Marchetti P, Eizirik DL.
Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.
Diabetologia. 2017; 60(4):656-667.
doi: 10.1007/s00125-016-4201-3.
Quesada-Candela C, Tudurí E, Marroquí L, Alonso-Magdalena P, Quesada I and Nadal A
Morphological and functional adaptations of pancreatic alpha-cells during late pregnancy in the mouse.
Metabolism. 2020; 102:153963.
doi:https://doi.org/10.1016/j.metabol.2019.153963
Bisphenol A regulates sodium ramp currents in mouse dorsal root ganglion neurons and increases nociception.
Sci Rep. 2019; 9(1):10306.
doi: 10.1038/s41598-019-46769-6.
Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes.
Sci Rep. 2019; 9(1):9515.
doi: 10.1038/s41598-019-45853-1.
DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway.
Diabetologia. 2019; 62(3):459-472.
doi: 10.1007/s00125-018-4782-0.
Tudurí E, Marroqui L, Dos Santos RS, Quesada I, Fuentes E, Alonso-Magdalena P.
Timing of Exposure and Bisphenol-A: implications for diabetes development.
Front Endocrinol (Lausanne). 2018; 9:648.
doi: 10.3389/fendo.2018.00648.
Dos Santos RS, Marroqui L, Grieco FA, Marselli L, Suleiman M, Henz SR, Marchetti P, Wernersson R, Eizirik DL.
Protective role of complement C3 against cytokine-mediated β-cell apoptosis.
Endocrinology. 2017; 158(8):2503-2521.
doi: 10.1210/en.2017-00104.
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.
EBioMedicine. 2018; 36:367-375.
doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27.
Coomans de Brachène A, Dos Santos RS, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL.
IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.
Diabetologia. 2018; 61(3):636-640.
doi: 10.1007/s00125-017-4536-4.
Long-Term GABA administration induces alpha cell-mediated beta-like cell neogenesis.
Cell. 2017; 168(1-2):73-85.e11.
doi: 10.1016/j.cell.2016.11.002.
TYK2, a candidate gene for type 1 diabetes, modulates apoptosis and the innate immune response in human pancreatic β-cells.
Diabetes. 2015; 64(11):3808-17.
doi: 10.2337/db15-0362.
Marroqui L, Masini M, Merino B, Grieco FA, Millard I, Dubois C, Quesada I, Marchetti P, Cnop M, Eizirik DL.
Pancreatic α cells are resistant to metabolic stress-induced apoptosis in type 2 diabetes.
EBioMedicine. 2015; 2(5):378-85.
10.1016/j.ebiom.2015.03.012.
Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells.
Elife. 2015; 4:e06990.
doi: 10.7554/eLife.06990.